- Sand Gravel & Aggregate, Portales
- Sandwich Shop Restaurants, Portales
- Savings Banks, Portales
- Scales Public, Portales
- School - Christian, Portales
- Scrap & Waste Materials, Portales
- Screen Printing, Portales
- Secondary Schools, Portales
- Security Alarm Systems - Home & Business, Portales
- Security Brokers & Dealers, Portales
- Security Control Systems & Monitoring, Portales - Polygraph, Lie Detector, CCTV, Fire Sensor Equipment, Etc
- Security Services, Portales
- Seeds & Bulbs Wholesale & Growers, Portales
- Semi Precious Turquoise, Portales
- Senior Citizens Information & Services, Portales
- Senior Citizens Service & Health Organizations, Portales
- Septic Tanks & Systems Contractors & Designers, Portales
- Sewer & Drain Cleaning & Repair, Portales - Drain Cleaner & Installation Services
- Sheet Metal Contractors, Portales - Sheet Metal Fabrication
- Sheet Metal Fabricators & Ductwork Contractors, Portales
- Sheriff's Department, Portales
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- Shoe Store - More, Portales
- Shopping & Shopping Services, Portales
- Signs, Portales
- Snack Foods, Portales
- Social Services & Welfare, Portales
- Speciality Food Stores, Portales
- Specialty Animal Services, Portales
- Specialty Stores, Portales
- Sporting Goods Stores, Portales
- Sports & Recreational Services, Portales
- Sports Bars & Lounges, Portales
- Sports Medicine, Portales - Doctors, Physicians & Surgeons
- Staffing & Support Services, Portales
- State Government, Portales
- State Parks, Portales
- Steak House Restaurants, Portales
- Steel & Metal Goods, Portales - Steel Distributors
- Stocks & Bond Brokers, Portales
- Substance Abuse Clinics, Portales - Alcoholism, Addiction & Drug Abuse Treatment Centers
- Swimming, Portales
- Swimming Pools, Portales
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